International Journal of Cardiology’de yayımlanan çalışmaya göre Q10 koenzimi desteği kalp hastalıklarına bağlı ölümlerde % 50’den fazla azalma sağlıyor (İng)
This Heart Critical Nutrient Cuts Heart Disease Deaths By 50%
A groundbreaking 5-year study published in the International Journal of Cardiology has shown that a daily supplement of Coenzyme Q10 (CoQ10) cuts the number of deaths from heart disease by more than 50 per cent.
The Swedish researchers conducted a trial on volunteers aged between 70 and 88. Half the participants took daily supplements of CoQ10 together with selenium, while the other half were given a placebo.
After a 5 year follow-up, researchers found that TWICE as many people in the placebo group had died of cardiovascular disease than in the CoQ10 group.
Only half as many died
A total of 443 male and female volunteers aged 70-88 years took part in the five-year study, which was carried out by researchers from Linköping University and Karolinska University Hospital. The trial was headed by Associated Professor Urban Alehagen, a cardiologist from the Heart Center of Linköping University, in collaboration with, among others Professor Ulf Dahlström.
The participants were randomly assigned to take either daily supplements 200 mg of coenzyme Q10 and 200 mcg of selenium yeast, or identical dummy pills (placebo).
After a five-year follow-up period, the scientists noted that more than twice as many people in the placebo group had died of cardiovascular disease compared with the group that got the combination of selenium and coenzyme Q10.
What’s more, the volunteers in the active treatment group showed distinct signs of improved heart health on two different accounts.
CoQ10: A Natural Heart booster
First of all, the researchers observed how levels of something called NT-proBNP (a substance that gets produced in the heart ventricles) were significantly higher in the placebo group, which is normally a warning sign that the heart muscle is working under increased stress. (In fact, high NT-proBNP levels are routinely used to predict potential heart failure in patients).
Secondly, the heart muscle function in the aCoQ10 group – as tested by an echocardiograph – was substantially better than what was seen in the placebo group. In other words, the echocardiographic measurements support the beneficial effect of the CoQ10 supplements on heart function.
Source: Alehagen U, et al. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation. Int J Cardiol. 2012. E-pub ahead of print.
CoQ10 Helps Control Blood Pressure, Too
In 2007, Australian researchers published a scientific review of 12 clinical studies, in which they concluded that coenzyme Q10 has the potential to lower blood pressure. Based on their findings, coenzyme Q10 can lower systolic blood pressure by up to 17 mmHg and diastolic blood pressure by up to 10 mmHg without side effects.Source: Coenzyme Q10 in the treatment of hypertension: A meta-analysis of the clinical trials; J Hum Hypertens, 2007;21(4):297-306
“Recharging” an energy-starved heart
Dozens and dozens of published studies show that patients with chronic heart failure benefit from taking CoQ10 supplements.
The treatment enables their heart muscle to contract with greater force, their exercise tolerance increases, and they can generally enjoy life in a fuller way because they are less likely to feel the limitations of their heart condition.
Heart patients are normally categorized according to the New York Heart Association (NYHA) Functional Classification (see below), which places patients in one of four groups based on how limited they are during physical activity (in terms of breathing, shortness of breath, chest pain etc.).
There are documented examples of heart patients who have improved 1-2 NYHA classes as a result of receiving coenzyme Q10 supplementation.
Sources: “Investigation of Pycnogenol(R) in combination with coenzymeQ10 in heart failure patients (NYHA II/III),” Belcaro G, Cesarone MR, et al, Panminerva Med, 2010 June; 52(2 Supple 1): 21-5 “Supplemental ubiquinol in patients with advanced congestive heart failure”, Langsjoen PH, Langsjoen AM.
How Coenzyme Q10 reduces inflammation
Regular readers of my weekday newsletter The Daily Health will already know that we’ve identified inflammation to be public enemy number no.1 in causing heart disease.
Well, now it turns out that Coenzyme Q10 has a promising role to play in reducing inflammation . . .
A group of Taiwanese researchers from Chung Shan Medical University and the Intensive Care Unit of Taichung Veterans General found in a recent study that CoQ10 successfully lowered levels of the inflammatory marker IL-6 (interleukin-6) in patients who were given a daily dose of 150 mg CoQ10 for 12 weeks.
The study was conducted on 40 patients with coronary artery disease who were randomly assigned to three groups: a placebo group, a 60 mg/day coenzyme Q10 group, or a 150 mg/day CoQ10 group. All groups followed the prescribed intervention for 12 weeks.
Levels of inflammatory markers, including IL-6, C-reactive Protein, and homocysteine, plus superoxide dismutase (an endogenous antioxidant enzyme) were measured before and after.
Subjects in the higher dosage (150 mg coenzyme Q10) group had significantly lower levels of IL-6 and malondialdehyde (a marker of lipid peroxidation).
At the same time, subjects in both Q10 groups had increased superoxide dismutase activity, which is a sign of improved antioxidant protection.
The researchers concluded that coenzyme Q10 taken at a dosage of 150 mg/day appears to decrease the inflammatory marker IL-6 in patients with coronary artery disease.