Randomize çalışmaya göre, vitaminler erkeklerde kardiyovasküler hastalığı önlemeye yönelik faydası yok (İng)


No Benefit of Multivitamins for Preventing Cardiovascular Disease in Men

A randomized, controlled trial showed that myocardial infarction, stroke, and death were not affected.

Observational studies of multivitamins for preventing cardiovascular disease (CVD) have yielded inconsistent and mostly negative results, as have randomized controlled trials of individual vitamins and minerals (including β-carotene, selenium, and vitamins B, C, and E). This randomized controlled trial that involved nearly 15,000 male physicians (mean age, 64) who were randomized to commercial daily multivitamins (Centrum Silver) or placebo is a companion analysis to a recently published study that showed a small benefit of multivitamin supplementation for preventing cancer (JW Gen Med Oct 25 2012). Follow-up continued for a median of 11 years.

No difference was found between the groups in risk for any major adverse CVD event, including myocardial infarction, stroke, or cardiac-related mortality. Multivitamin supplementation also was not beneficial in the small subgroup of men with histories of CVD at study entry (5% of participants).

Comment: These findings appear to disprove the suggestion (or hope) that vitamin supplementation prevents CVD, at least in men. The cardiovascular and cancer outcomes from this trial will help clinicians answer patients’ questions about the value of multivitamins; additional results from this study (i.e., on preventing eye disease and cognitive decline) are forthcoming.

— Thomas L. Schwenk, MD

Published in Journal Watch General Medicine November 15, 2012


Sesso HD et al. Multivitamins in the prevention of cardiovascular disease in men: The Physicians’ Health Study II randomized controlled trial. JAMA 2012 Nov 7; 308:1751. (http://dx.doi.org/10.1001/jama.2012.14805)

Medline abstract (Free)